18 February 2023
An enhanced collaborative tool at hand to support access to innovative long-acting therapeutics
Seattle – During a workshop held prior to the Conference on Retroviruses and Opportunistic Infections (CROI), Dr. Charles Flexner, the Principal Investigator of the Long-Acting/Extended Release Antiretoviral Research Resource Program (LEAP) today announced, on behalf of all partners, a new version of the Long-Acting Therapeutics Patents and Licences Database LAPaL.
Launched in 2021 by the Medicines Patent Pool with support from Unitaid, LAPaL is a free online dynamic resource that provides information on technical features, development status and intellectual property status of selected long-acting therapeutics that could have health impact in low- and middle-income countries. LAPaL aims to facilitate collaborations in the long-acting space and advocates for access to long-acting therapeutics with potential public health benefit, by fostering development opportunities for fit-for purpose technologies to be used by all those needing them, everywhere, including in resource-limited settings.
The new version of LAPaL is enabled by a collaboration with the Center of Excellence of Long Acting Therapeutics (CELT) of the University of Liverpool and LEAP. The platform now includes an integrated LA compounds landscape with an interactive visualisation dashboard to track long-acting therapeutics clinical development and regulatory approval status worldwide. As of now, LAPaL includes 10 long-acting platform technologies with many potential applications including HIV prevention and treatment. Today’s release includes five compounds and more are expected in the coming weeks, including relevant combination products, multipurpose technologies and monoclonal antibodies. A dedicated team of experts will continue to curate and expand the database content based on reliable public sources of information with potential additional contributions and validation certificates from innovators.
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About LAPaL partners:
LAPaL is hosted and coordinated by the Medicines Patent Pool in collaboration with the Center of Excellence of Long Acting Therapeutics (CELT) of the University of Liverpool with support from Unitaid and the Long-Acting/Extended Release Antiretoviral Research Resource Program (LEAP).
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The Medicines Patent Pool (MPP) is a United Nations-backed public health organisation working to increase access to and facilitate the development of life-saving medicines for low- and middle-income countries. Through its innovative business model, MPP partners with civil society, governments, international organisations, industry, patient groups, and other stakeholders to prioritise and license needed medicines and pool intellectual property to encourage generic manufacture and the development of new formulations.
To date, MPP has signed agreements with 22 patent holders for 13 HIV antiretrovirals, one HIV technology platform, three hepatitis C direct-acting antivirals, a tuberculosis treatment, a cancer treatment, four long-acting technologies, a post-partum haemorrhage medicine, three oral antiviral treatments for COVID-19 and 16 COVID-19 technologies.
MPP was founded by Unitaid, which continues to be MPP’s main funder. MPP’s work on access to essential medicines is also funded by the Swiss Agency for Development and Cooperation (SDC), Government of Canada, the World Intellectual Property Organization (WIPO) and the Government of Flanders. MPP’s activities in COVID-19 are undertaken with the financial support of the Japanese Government, the French Ministry for Europe and Foreign Affairs, the German Agency for International Cooperation, and SDC.